Correlations between arterial elasticity and cardiovascular risk factors

Liu Hong; Yang Qing; Liu Xiaoli; Wang Yuan

doi:10.3760/cma.j.issn.1673-4777.2015.10.001

Abstract：Objective To investigate the correlations of arterial elasticity and cardiovascular risk factors.Methods Totally 181 subjects from May 2013 to October 2014 were enrolled and divided into normal carotid-femoral artery PWV (cfPWV) group (＜ 10 m/s,87 subjects) and increased cfPWV group (≥ 10 m/s,94 subjects).Age,waistline and body mass index (BMI) were recorded;blood pressure,blood glucose (BG),blood lipid,insulin,insulin resistance (HOMA-IR),high sensitivity C-reactive protein (hs-CRP),endothelins (ET),nitricoxide (NO) and catroid-radial artery PWV (crPWV) were measured.The correlations of cfPWV,crPWV with above factors were analyzed.Results The waistline,systolic blood pressure (SBP),diastolic blood pressure (DBP),triglyeride (TG),BG,hs-CRP,HOMA-IR,ET,NO and crPWV in increased cfPWV group were significantly different from those in normal cfPWV group [(85 ± 9) cm vs (81 ± 11) cm,(139±19) mmHgvs (121 ±17) mmHg,(91 ±12) mmHg vs (82±13) mmHg,(2.5 ±1.3) mmol/L vs (1.6± 1.0) mmol/L,(5.8 ± 1.6) mmol/L vs (5.2 ±0.5) mmol/L,(2.8 ± 1.4) mg/L vs (1.6 ±0.6) mg/L,(5.9 ±2.8) vs (4.0 ±2.1),(81 ±21) ng/L vs (74 ±21) ng/L,(43 ±21) μmol/L vs (56 ± 25) μmol/L,(10.3 ± 1.5) m/s vs (9.0 ± 1.5) m/s] (all P ＜ 0.05).Pearson correlation analysis showed that cfPWV was correlated with SBP,age,DBP,BG,TG,waistline,total cholesterol (TC),HOMA-IR,ET,NO and hs-CRP (P ＜ 0.05);crPWV was correlated with DBP,age,SBP and NO (P ＜0.05).Multiple linear stepwise regression showed that SBP,age,BMI,TC and hs-CRP were independent factors of cfPWV (P ＜ 0.05);SBP,DBP,BMI,age,waistline and NO were independent factors of crPWV (P ＜0.05).Conclusion Age,blood pressure,blood glucose,waistline,BMI,TC and hs-CRP and NO are independent factors of arterial elasticity.