Effect of epalrestat combined with mecobalamin in treating diabetic peripheralneuropathy
Huang Cuiling
Abstract：Objective To investigate the effect of epalrestat combined with mecobalamin in treating diabetic peripheralneuropathy (DPN).Methods Totally 96 patients with DPN from July 2013 to July 2014 were randomly divided into control group (48 cases) which was orally administrated with mecobalamin (3 times/d for 12 weeks) and treatment group (48 cases) which was orally administrated with mecobalamin combined with epalrestat (3 times/d for 12 weeks).The nerve conduction velocity and toronto clinical scoring system (TCSS) scores were compared between the two groups before and after treatment.Results The total effective rate in treatment group was significantly higher than that in control group [89.6％ (43/48) vs 64.6％ (31/48),P ＜ 0.05].After treatment,the motor nerve conduction velocity (MNCV),sensory nerve conduction velocity (SNCV) median nerve and peroneal nerve in control group had no significantly changes (P ＞ 0.05) ; they were significantly increased in treatment group [median nerve MNCV:(55 ± 6) m/s vs (38 ± 6) m/s,median nerve SNCV:(48 ± 5) m/s vs (38 ±4) m/s; peroneal nerve MNCV:(47 ±4) m/s vs (38 ±4) m/s,peroneal nerve SNCV:(46 ± 6) m/s vs (40 ±5) m/s] (P ＜0.05).After treatment,the MNCV,SNCV of median nerve and peroneal nerve in treatment group were significantly higher than those in control group [median nerve MNCV:(55 ± 6) m/s vs (42 ±9) m/s,median nerve SNCV:(48 ±5) m/s vs (40 ±4) m/s; peroneal nerve MNCV:(47 ±4) m/s vs (40 ±5) m/s,peroneal nerve SNCV:(46 ±6) m/s vs (40 ±6) m/s] (P ＜0.05).After treatment,the TCSS score of treatment group was significantly reduced compared with that before treatment [(9.8 ± 3.5) scores vs (13.4 ± 3.9) scores] ; it was also significantly lower than that of control group [(9.8 ± 3.5) scores vs (11.3 ± 2.4) scores] (P ＜ 0.05).Conclusion Epalrestat combined with methylcobalamin in treating DPN can improve symptoms and nerve conduction velocity compared with single methylcobalamin.
Keywords：Diabetic neuropathiesMethylcobalaminEpalrestatNerve conduction velocity
Publication Date：2015-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1315-1318 )