Effect and safety of different platinum drugs combined with vinorelbine in treating advanced non-small cell lung cancer
Abstract：Objective To explore the effect and safety of different platinum drugs combined with vinorelbine in treating advanced non-small cell lung cancer (NSCLC).Methods Totally 92 patients of NSCLC were randomly divided into cisplatin group (34 cases) administrated with cisplatin 40 mg/m2 on the 1st-3rd day,carboplatin group (31 cases) administrated with carboplatin 100 mg/m2 on the 1st-3rd day,and nedaplatin group (27 cases) administrated with nedaplatin 40 mg/m2 on the 1st-3rd day; all the three groups were treated with vinorelbine 30 mg/m2 on the 1 st day and 8th day.The short-term efficacy and adverse reactions were evaluated after 4 cycles of chemotherapy.Results There were 87 cases who completed 4 cycles of chemotherapy,including 32 cases in cisplatin group,29 cases in carboplatin group and 26 cases in nedaplatin group.In cisplatin group,there were 2 of complete response,12 of partial response,10 of stability and 8 of progression,showing an efficacy of 43.8％ (14/32) ; in carboplatin group,there were 1 of complete response,12 of partial response,10 of stability and 6 of progression,showing an efficacy of 44.8％ (13/29) ; in nedaplatin group there were 2 of complete response,10 of partial response,9 of stability and 5 of progression,showing an efficacy of 46.2％ (12/26).No statistical differences regarding short-term efficacy of chemotherapy were found among the three groups (P ＞ 0.05).The incidence of nausea/vomiting in cisplatin group,carboplatin group and nedaplatin group was 93.8％ (30/32),69.0％ (20/29) and 38.5％ (10/26),respectively,showing statistical differences (P ＜ 0.05).In cisplatin group,carboplatin group and nedaplatin group,the incidence of neutropenia was 35.7％ (12/32),51.7％ (15/29) and 30.8％ (8/26) ; the incidence of thrombocytopenia was 18.8％ (6/32),27.6％ (8/29) and 34.6％ (9/26); the incidence of alopecia was 81.3％ (26/32),79.3％ (23/29),and 80.8％ (21/26),showing no statistically differences among the three groups (all P ＞ 0.05).Conclusions The therapeutic effects of cisplatin,carboplatin and nedaplatin combined with vinorelbine are not statistically different in patients with advanced NSCLC,and the gastrointestinal reactions of nedaplatin,such as nausea and vomiting,are the most slight.
Keywords：Cancer,non-small cell lungCisplatinCarboplatinNedaplatinVinorelbine
Publication Date：2015-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1289-1292 )