Expression of cylindromatosis in pancreatic ductal adenocarcinoma
Abstract：Objective To evaluate the expression of cylindromatosis (CYLD) in pancreatic ductal adenocarcinoma (PDAC),and to identify the value of CYLD in regard with predicting the prognosis of PDAC.Method The paraffin-embedded samples and clinical data of 57 patients of PDAC undergoing radical excision were collected.Immunohistochemical staining was performed to determine the expression level of CYLD,and the prognostic value of CYLD was evaluated.Result Totally 34 patients (59.6％) showed a high expression of CYLD (CYLD score ≥ 2 scores);23 patients (40.4％) showed a low expression of CYLD (CYLD score ＜ 2 scores).The age,vascular invasion,preoperative carcinoma antigen 199 level,preoperative carcino-embryonic antigenlevel and preoperative total bilirubin (TBIL) level were correlated with prognosis of PDAC (x2 =6.131,P=0.013;x2=4.094,P=0.043;x2 =7.188,P=0.007;x2 =7.660,P=0.006;x2 =8.610,P=0.003).Level of CYLD was positively correlated with vascular invasion(r =0.335,P =0.008) and it was negatively correlated with preoperative TBIL level (r =-0.379,P =0.004).Patients with low expression of CYLD had a significantly longer median survival time compared with patients with high expression of CYLD (9.3 months vs 5.2 months) (P =0.047).Patients with high preoperative TBIL level and low expression of CYLD had a significantly longer median survival time compared with others (12.5 months vs 5.2 months) (P =0.002).Conclusion Low expression of CYLD can indicate an improved prognosis after curative surgery in PDAC patients with high preoperative TBIL level.
Keywords：Pancreatic ductal adenocacinomaCylindromatosisPrognosis
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1160-1165 )