Study of procalcitonin in patients with hepatic failure
Zhang Guodong
Abstract：Objective To explore the value of serum procalcitonin in patients with hepatic failure.Methods Totally 106 patients with hepatic failure from January 2009 to October 2014 were enrolled and divided into infection group (75 cases) and non-infection group (31 cases).After anti-infection treatment,75 cases in infection group weredivided into high procalcitonin group (33 cases) and low procalcitonin (42 cases) according to the level of serum procalcitonin.Twenty three cases of liver failure patients with calcitonin peptide ＜ 0.5 μg/L underwent serum procalcitonin reexamination within 48 h and divided into procalcitonin increasing ＞ 1 time group (10 cases) and procalcitonin increasing ＜ 1 time group (13 cases).The value of procalcitonin for early diagnosis and prognosis prediction of bacterial infections were evaluated.Results In infection group,there were 72 cases with procalcitonin≥0.5 μg/L [96.0％ (72/75)],significantly more than that in non-infection group [35.5％ (11/31)] (x2 =47.28,P ＜ 0.01).In high procalcitonin group,21 cases were dead [63.6％ (21/33)],significantly more than that in low procalcitonin group[14.3％ (6/42)] (x2 =19.53,P ＜ 0.01).There were 6 cases in procalcitonin increasing ＞ 1 time group and 2 cases in procalcitonin increasing ＜ 1 time group were complicated with infection with significantly differece (P ＜ 0.05).Conclusion Serum procalcitonin is important for early diagnosis and prediction of infection in hepatic failure patients;it is also important for prediction of hepatic failure complicated with infection.
Keywords：Hepatic failureProcalcitoninBacterial infectionDiagnosisPrognosis
Publication Date：2015-08-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1154-1156 )