Value of non-invasive parameters in predicting severity of chronic hepatitis B
Zhang Dong
Jiang Ping
Yang Ting
Hao Xiuxian
Lou Yuangui
Abstract：Objective To assess the value of non-invasive parameters in predicting severity of chronic hepatitis B (CHB).Methods Clinical data of 78 patients with untreated CHB from January to December 2013 were retrospectively analyzed.The demographic characteristics and laboratory parameters were recorded.The ratioof aspartate aminotransferase (AST) to alanine aminotransferase (ALT) (AAR),ratio of AAR to platelet count (AARPRI),ratio of AST toplatelet count (APRI),and ratio age to platelet count (API) were calculated.Thepercutaneous liver biopsy was preformed to determine the mild,moderate/severe inflammation,mild hepatic fibrosis and moderate/severe hepatic fibrosis.The correlations of between AAR,AARPRI,APRI,API,age and degree of hepatic inflammation and fibrosis were analyzed.Results AAR,AARPRI,APRI,API were (0.78 ±0.37),(0.58 ±0.28),(0.83 ±0.47),(2.59 ± 1.85) in mild hepatitis patients;they were (0.73 ± 0.25),(0.61 ± 0.30),(3.15 ± 1.93),(3.92 ± 2.31) in moderate/severe hepatitis patients,respectively.AAR,AARPRI,APRI,API were (0.76 ± 0.33),(0.57 ± 0.27),(0.85 ± 0.50),(2.70 ± 1.87) in patients with mild hepatic fibrosis;they were(0.75 ± 0.31),(0.62 ± 0.31),(3.18 ± 1.92),(3.80 ± 2.36) in patients with severe hepatic fibrosis.APRI and API were significantly higher in moderate/severe hepatitis patients than those in mild hepatitis patients.The age,AST,ALT,AARPRI,APRI and API were significantly correlated with degree of hepatic inflammation (r =0.23,0.31,0.22,0.25,0.37,0.36) and fibrosis (r =0.31,0.30,0.22,0.24,0.38,0.31) (P ＜ 0.05).The independent risk factors of degree of hepatic inflammation included APRI (odds ratio =2.35,P =0.01) and age (odds ratio =1.04,P ＜ 0.01);the independent predictors of hepatic fibrosis included AARPRI (odds ratio =3.80,P =0.07),age (odds ratio =1.04,P =0.02),and ALT (odds ratio =1.01,P ＜ 0.01).Conclusion The APRI can help to predict the severity of liver disease in patients with CHB.
Keywords：Chronic hepatitis BLiver fibrosisLiver histology necrosis and inflammation
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1149-1153 )