Effect of tiotropium combined with low dose theophylline on stable chronic obstructive pulmonary disease
Guo Junhua
Huang Siyun
Li Jianguo
Abstract：Objective To observe the effect of tiotropium combined with low-dose theophylline on stable chronic obstructive pulmonary disease (COPD).Methods Totally 112 patients with moderate to severe stable COPD from January 2010 to January 2013 were enrolled and randomly divided into tiotropium group (38 cases) inhaling tiotropium (18 μg,once/d),theophylline group (38 cases) taking low dose theophylline (100 mg,1 times/12 h),and combined group (36 cases) taking tiotropium combined with low dose theophylline.The pulmonary function,exercise tolerance (6 min walking distance),life quality (St george respiratory questionnaire) and frequency of AECOPD during therapy were assessed before and 6 months after treatment.Results Six months after treatment,the forced expiratory volume in one second (FEV1),ratio of FEV1 and forced vital capacity in percentage (FEV1/FVC％) and FEV1/predicted％,exercise tolerance,life quality were all improved in tiotropium group [(1.2 ±0.4) L vs (1.1 ±0.3) L,(55 ±10)％ vs (49 ±8)％,(53 ±9)％ vs (49 ±8)％,(289 ± 27) mvs (238±23) m,(41±5) scorevs (50±4) score] and combined group [(1.2±0.4) Lvs (1.1 ± 0.3) L,(56±8)％ vs (49±9)％,(53±10)％ vs (47±9)％,(294±28) mvs (237±26) m,(41 ±5) scores vs (50 ± 3) scores] (P ＜ 0.05),but there was no significant difference in theophylline group (P ＞ 0.05).The FEV1,FEV1/FVC％ and FEV1/predicted％,exercise tolerance and life quality were improved in tiotropium group and combined group compared with those in theophylline group [(1.1 ± 0.4) L,(52 ± 10) ％,(50 ± 11) ％,(240 ± 29) m,(47 ± 4) scores] after treatment (P ＜ 0.05),but there was no differencebetween tiotropium group and combined group (P ＞ 0.05).The frequency of AECOPD was reduced significantly in combined group compared with that in tiotropium group (3 people/half year vs 5 people/half year,P ＜ 0.05).Conclusion Tiotropium combined with low dose theophylline can not only improve lung function,exercise tolerance and life quality,but also can significantly reduce the frequency of acute exacerbation in patients with moderate to severe stable COPD.
Keywords：Chronic obstructive pulmonary diseaseTiotropiumLow-dose theophyllineStable period
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1126-1130 )