Effect of hydrochloride trimetazidine on echocardiography, oxidative stress and hemodynamics in coronary heart disease patients with heart failure

Zou Qingmei; Liu Yao; Gao Jinquan; Zhang Yaxi; Huang Lin

doi:10.3760/cma.j.issn.1673-4777.2015.08.007

Abstract：Objective To explore the effect of hydrochloride trimetazidine onechocardiography,oxidative stress and hemodynamics in coronary heart disease patients with heart failure.Methods Totally 82 patients of coronary heart disease with heart failure from September 2010 to June 2013 were enrolled and randomly divided into control group (41 cases)given conventional treatment of heart failure and observation group (41 cases) given hydrochloride trimetazidine (20 mg,3 times/d) in addition to the conventional treatment.After 6 months of treatment,the changes of echocardiography,oxidative stress and hemodynamics were compared.Results After treatment,the left ventricular end diastolic diameter,left ventricular end systolic diameter,left ventricular end systolic volume,left ventricular end diastolic volume and left ventricular ejection fraction in observation group were significantly improved compared with those in control group [(40 ± 5) mm vs (43 ± 5) mm,(24 ± 4) mm vs (27 ± 4) mm,(23 ±5) mlvs (26±6)ml,(70±17) mlvs (76±15) ml,(70±17)％ vs (74±6)％](P＜0.05);the whole blood viscosity,relative viscosity of blood shear rate,amplitude of plasma viscosity and fibrinogen were significantly improved [(3.8±1.2) vs (4.2±1.2),(2.3±0.5) vs (2.8±0.6),(1.5±0.5) mPa/s vs (1.6 ± 0.5) mPa/s,(3.0 ± 1.1) g/L vs (3.6 ± 1.2) g/L,P ＜ 0.05].The parameters of oxidative stress,such as malondialdehyde,superoxide dismutase,nitric oxide and endothelin 1 in observation group were significantly improved than those in control group[(5.3 ± 1.4)μmol/L vs (6.3 ± 1.3)μmol/L,(114 ± 26) kU/L vs (121 ± 26) kU/L,(68 ± 15) μmol/L vs (60 ± 14) μmol/L,(90 ± 19) ng/L vs (90 ± 19) ng/L] (P ＜ 0.05).Mild gastrointestinal reaction occurred in 3 cases (7.3％) of observation group and 2 cases (4.9％) of control group.Conclusion Hydrochloride trimetazidine can regulate the oxidative stress and hemodynamics to imProve the cardiac function.