Manifestations and risk factors of cardiac involvement in patients with Takayasu's arteritis
Wan Jin
Pan Lili
Ci Weiping
Liao Hua
Wang Tian
Abstract：Objective To explore manifestations and risk factors of cardiac involvement in patients with Takayasu's arteritis (TA).Methods Data of 55 TA patients complicated with cardiac injury among 85 TA patients,including clinical manifestations and results of physical,laboratory,imaging examination,were retrospectively analyzed.The cardiac injury was assessed by echocardiography and coronary CT angiography CT.Relative clinical data of TA patients complicated with cardiac injury were compared withTA patients without cardiac injury.Results In the 55 patients,47 were female and 8 were male.The time of confirmed diagnosis in TA patients with cardiac injury was significantly later [36 (9,168)months vs 12 (6,24) months],compared with that in TA patients without cardiac injury;meanwhile chest pain and blood pressure difference ＞ 10 mmHg between right-to-left sides were more like to occur [27.3％ (15/55) vs 6.7％ (2/30),69.1％ (38/55) vs 46.7％ (14/30)] (P ＜ 0.05).The proportions of patients with increased erythrocyte sedimentation rate and C reactive protein were not statistically different between TA patients with or without cardiac injury [63.6％ (35/55) vs 56.7％ (17/30),58.2％ (32/55) vs 53.3％ (16/30)] (P ＞ 0.05).In TA patients with cardiac injury,there were 13 of type Ⅰ (23.6％),11 of type Ⅱ (20.0％),28 of type Ⅲ (50.9％),1 of type Ⅰ +Ⅳ (1.8％),2 of type Ⅲ+ Ⅳ (3.6％);30 patients (54.5％) had hypertensive heart disease,including 18 of renal arterial stenosis or occlusion the onset hypersension were of (28 ± 14) years,which was younger than those without renal arterial involvement [(44 ± 14) years] (P ＜ 0.05);6 patients (10.9％) had old of age cardiomyopathy,showing a lower left ventricular ejection fraction and a younger onset age compared with patients without acardiomyopathy [(34±8)％vs (66±7)％,(15±13) years vs (25±11) years] (P＜0.05);36 patients (65.5％) had valvular disease;9 patients (16.4％) had coronary artery disease;7 patients (12.7％) had pulmonary hypertension with rest pulmonary arterial systolic pressure of (62 ± 22) mmHg,but there was no manifestation of right heart failure.Multivariate analysis showed that higher CRP was an independent risk factor of pulmonary hypertension [odds ratio(OR) =0.082,95％ confidence interval (CI):0.007-0.965,P ＜ 0.05],mitral valve regurgitation (OR =0.192,95％ CI:0.040-0.929,P ＜ 0.05) and tricuspid regurgitation (OR =0.093,95％ CI:0.011-0.761,P ＜ 0.05).Conclusion Cardiac involvement is not rare in TA;special attention should be paid to the cardiac manifestation,and early diagnosis and treatment can reduce cardiac injury.
Keywords：Takayasu's arteritisCardiac injuryClinical researchRetrospective study
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1103-1107 )