Changes and significance of blood B-type natriuretic peptide in patients with acute pulmonary embolism
Chen Yunxia
Abstract：Objective To explore the clinical significance of blood B-type natriuretic peptide (BNP) for risk stratification,treatment and prognostic evaluation in patients with acute pulmonary embolism.Methods Totally 52 consecutive patients with acute pulmonary embolism from March 2013 to March 2014 were enrolled.The concentration of blood BNP was measured and the right ventricular function was detected by echocardiography after admission.The patients were classified into massive,sub-massive and non-massive pulmonary embolism group;in addition,the patients were divided into right ventricular normal function group and right ventricular dysfunction group based on the results of echocardiography.Results The BNP concentration in massive and sub-massive pulmonary embolism group were both higher than that in non-massive pulmonary embolism group [(795 ± 22),(408 ± 21) ng/L vs (86 ± 17) ng/L] (P ＜ 0.01),and was significantly higher in right ventricular dysfunction group than that in right ventricular normal function group [(675 ± 36) ng/L vs (392 ± 23) ng/L] (P ＜ 0.05).The incidence of adverse events in right ventricular dysfunction group was significantly higher than that in right ventricular normal function group [64.7％ (11/17) vs 34.3 ％ (12/35)] (P ＜ 0.05).Conclusion In patients with acute pulmonary embolism,higher BNP level is,assoiated with the serions condition and more incidence of adverse events;BNP combined with right ventricular function has important value for risk stratification acute pulmonary embolism.
Keywords：Acute pulmonary embolismBrain natriuretic peptideRight ventricular functionRisk stratification
Publication Date：2015-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 982-984 )