Correlation between serum uric acid level and coronary artery disease in patients with hypertension
Zhang Wenchao
Liu Siren
Tian Ying
Lu Rui
Dong Lei
Abstract：Objective To explore the correlation between serum uric acid level and coronary heart disease in patients with hypertension.Methods Three hundred and twenty patients with hypertension from January 2012 to December 2014 were selected and divided into CHD group (130 cases) and non-CHD group (190 cases) by coronary CT or coronary angiography findings.The patients in CHD group were divided into single-branch lesion,two-branch lesion and three-branch lesion subgroup,according to the coronary angiography.The serum uric acid and high sensitivity C reactive protein (hs-CRP) were measured and compared.The lesion segments were calculated based on revised Coronary Segmentation Method of American Heart Association;the correlation between accumulated number of lesion segments and uric acid or hs-CRP levels was analyzed.Results The serum uric acid was higher in CHD group than that in non-CHD group [(388 ±56)μmol/L vs (350 ±54)μmol/L],so was the hs-CRP [(7.5 ± 3.7) mg/L vs (6.5 ± 3.3) mg/L] (both P ＜ 0.05).Levels of the uric acid and hs-CRP significantly increased with the degree of coronary artery lesions [single-branch lesion:(381 ± 56) μmol/L and (6.2 ± 2.7) mg/L,two-branch lesion:(390 ± 47) μmol/L and (6.5 ± 3.3) mg/L,three-branch lesion:(396 ± 54) μmol/L and (6.9 ± 3.3) mg/L] (P ＜ 0.05).Spearman correlation analysis revealed that the number of lesion-segments was positively correlated with serum uric acid and hs-CRP (r =0.59,P =0.02;r =0.49,P =0.03).Conclusion The serum uric acid level is correlated with the severity of coronary artery disease in patients with hypertension.
Keywords：Coronary diseaseUric acidHigh-sensitivity C-reactive protein
Publication Date：2015-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 965-967 )