Influence of different doses of atorvastatin on recent blood lipid and cardiovascular events after intervention therapy in patients with acute myocardial infarction
Zhang Zhenling
Ren Peng
Ma Li
Gao Fangming
Abstract：Objective To explore the influence of different doses of atorvastatin on recent hs-CRP,blood lipid and cardiovascular events after intervention therapy in patients with acute myocardial infarction (AMI).Methods Totally 120 patients with AMI undergoing emergency percutaneous coronary intervention from January to September 2014 were randomly divided into 20 mg group (60 cases) given 20 mg atorvastatin in addition to conventional treatment,and 40 mg group (60 cases) given 40 mg atorvastatin in addition to conventional treatment.After 1 week of treatment,the levels of hs-CRP and blood lipid were measured;after 1 month of treatment,the adverse cardiovascular events (frequency of angina) were recorded and compared between the two groups.Results One week after treatment,the levels of hs-CRP,high density lipoprotein cholesterol (HDL-C),total cholesterol and low density lipoprotein cholesterol (LDL-C) were all significantly decreased in both 20 mg group [(6.1 ± 1.6) mg/L vs (15.6±3.6) mg/L,(0.86 ±0.20) mmol/L vs (1.00±0.24) mmol/L,(3.7 ±0.6) mmol/L vs (4.5 ± 1.0) mmol/L,(2.3 ± 0.6) mmol/L vs (3.0 ± 0.9) mmol/L] and 40 mg group [(6.0 ± 1.8) mg/L vs (15.6 ± 5.3) rng/L,(0.81 ±0.15) mmoL/L vs (0.97 ±0.25) mmol/L,(2.9 ±0.5) mmol/L vs (4.1 ±0.9) mmol/L,(1.7 ± 0.4) mmol/L vs (2.7 ± 0.8) mmol/L] (P ＜ 0.05);the level of LDL-C after treatment in 40 group was significantly lower than that in 20 group (P ＜0.01).There was no cardiac death,and the frequency of angina in 20 mg group was significantly higher than that in 40 mg group [43.3％ (26/60) vs 16.7％ (10/60),x2 =5.079,P =0.024].Conclusion In patients with AMI,atorvastatin can effectively reduce the levels of hs-CRP and blood lipid level during an early period after percutaneous coronary intervention;in addition,40 mg atorvastatin is better than 20 mg atorvastatin regarding decreasing blood lipid levels and frequency of angina.
Keywords：Acute myocardial infarctionAtorvastatinHypersensitive C-reactive proteinLipid levelsCardiovascular events
Publication Date：2015-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 955-957 )