Cardiac function and brain natriuretic peptide in patients with acute coronary syndrome complicated with rheumatoid arthritis
Pan Lili
Wang Tian
Abstract：Objective To investigate the cardiac function and brain natriuretic peptide (BNP) level in patients with acute coronary syndrome (ACS) complicated with rheumatoid arthritis (RA).Methods Sixty-eight ACS patients complicated with RA (observation group) and 65 ACS patients without RA (control group) from January 2012 to June 2013 were enrolled.The age,gender,body mass index (BMI),blood pressure,relative risk factors of cardiovascular disease were recorded and compared between the two groups.The levels of high sensitivity C reactive protein (hs-CRP),erythrocyte sedimentation rate (ESR),serum triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),homocysteine (Hcy) and serum brain natriuretic peptide (BNP) were compared between the two groups.The echocardiography was used to determine the changes of cardiac morphology and function.Results The BMI was significantly higher in observation group than that in control group [(28 ±4) kg/m2 vs (25 ±4) kg/m2].There were no differences regarding the age,gender,blood pressure,relative risk factors of cardiovascular disease,and the levels of TG,TC and LDL-C between the two groups.The HDL level was significantly lower in observation group than that in control group[(1.0 ±0.3) mmol/L vs (1.2 ± 0.2) mmol/L] (P ＜ 0.05).The serum CRP,ESR and Hcy levels in observation group were significantly higher than those in control group[(10 ± 6) mg/L vs (4 ± 3) mg/L,(28 ± 16) mm/1 h vs (9 ±4) mm/1 h,(17 ±6) μmol/L vs (14 ±4) μmol/L] (P＜0.05).The level of BNP was significantly higher and the LVEF was significantly lower in observation group than that in control group [(387 ± 226)ng/L vs (258 ± 139) ng/L,(44 ± 13)％ vs (61 ± 10)％].Reduction of diastolic function was found in 66 cases (96.7％) of observation group,higher than that in control group [62.3％ (40/65)] (P ＜ 0.01).Conclusions ACS patients complicated with RA are more likely to be afflicted with the reduction of left ventricular functions with higher BNP compared with ACS patients without RA,which might be related to the inflammation.
Keywords：Rheumatoid arthritisAcute coronary syndromesCardiac function
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 938-941 )