Correlation between carotid plaque and serum 1, 25-dihydroxyvitamin D3 in diabetic patients
Song Yuling
Liu Changmei
Abstract：Objective To investigate the relation between carotid plaque formation and serum 1,25-dihydroxyvitamin D3 in diabetes mellitus patients.Methods A total of 82 diabetes patients (diabetes group) from September 2013 to February 2014 were enrolled and divided into plaque subgroup (48 cases) and non plaque subgroup (34 cases) according to the results of ultrasound;40 healthy people were selected as control group.The general information and related biochemical indicators were collected;the level of serum 1,25 (OH)2 D3 was measured.Results The level of serum 1,25 (OH)2D3 in diabetes group was significantly lower than that in control group [(12 ±5) μg/L vs (22 ±5) μg/L],in plaque subgroup was significantly lower than that in non plaque subgroup [(8.3 ± 1.4) μg/L vs (18.0 ±2.8) μ/L] (P ＜0.01).Pearson correlation analysis showed that carotid plaque formation was positively correlated with age,smoking,body mass index (BMI),systemic blood pressure (SBP),low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin A1c (HbA1c) (r =0.60,0.16,0.43,0.50,0.45,0.32,P ＜0.05 or P ＜0.01);it was negatively correlated with serum 1,25 (OH)2D3 (r =-0.55,P ＜ 0.01).Multivariate logistic regression revealed that the risk factors of carotid plaque formation in diabetes patients included age [OR =1.076,95％ confidence interval(CI):1.040-1.115),smoking (OR =3.852,95％ CI:1.821-7.905),BMI (OR =1.623,95％ CI:1.030-1.720),SBP (OR=1.295,95％CI:1.040-1.493),HbA1c (OR =1.054,95％CI:1.032-1.260) and LDL-C (OR=1.642,95％CI:1.135-2.320) (all P ＜0.05),while 1,25 (OH)2D3 was the protection factor for carotid plaque formation (OR =0.986,5％CI:0.864-0.996,P ＜0.01).After adjusting correction factors,the level of serum 1,25 (OH)2D3 was independently correlated with carotid plaques formation.Conclusion Low level of serum 1,25 (OH)2D3 level is closely related to the formation of carotid plaque in diabetes patients.
Keywords：Diabetes mellitusCarotid plaque1,25-dihydroxyvitamin D3
Publication Date：2015-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 834-837 )