Effect and safety of sitagliptin in treatment of type 2 diabetes mellitus in elderly patients
Abstract：Objective To evaluate the effect and safety of sitagliptin in treatment of type 2 diabetes in elderly patients.Methods One hundred and eight hospitalized elderly patients (≥ 65 years old) with type 2 diabetes were included and administrated with sitagliptin (100 mg daily) besides original therapy.The haemoglobin A1c (HbA1c),fasting blood glucose (FBG) and 2 hour postprandial glucose (2 h PBG) were compared before and after treatment.Results After treatment,the HbA1c decreased from (7.4 ± 1.3)％ to (6.9 ± 0.7)％ (P =0.02).In patients with high fasting hyperglycemia as well as high postprandial hyperglycemia;FBG,2 h PBG and HbA1c were significantly decreased compared with those before treatment [FBG:(7.0 ±1.1) mmol/L vs (8.3 ± 1.5) mmol/L,PBG:(9.6 ± 0.5) mmol/L vs (14.0 ± 3.4) mmol/L,HbA1 c:(7.0 ±0.4) ％ vs (8.1 ± 1.5) ％,P ＜ 0.05].No irritation,nausea,vomiting,abdominal pain,diarrhea and other reactions occurred in all patients during treatment.Conclusion Sitagliptin is effective and safe treating type 2 diabetes in elderly patients.
Keywords：Diabetes mellitus,type 2SitagliptinElderlySafety
Publication Date：2015-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 831-833 )