Effect and safety of aspirin combined with Huoxue Huayu proprietary Chinese medicine in ischemic cerebrovascular disease in elderly patients: a Meta-analysis
Xie Hongjuan
Wang Yuqin
Li Xiaoling
Liu Chen
Abstract：Objective To evaluate the effective and safety of aspirin combined with Huoxue Huayu proprietary Chinese medicine in ischemic cerebrovascular disease in elderly patients by using Meta-analysis.Methods The prescriptions of patients ≥60 years old who received aspirin due to cerebral infarction,stroke,cerebral ischemia and cerebral ischemic infarction from January 2012 to June 2012 were collected.Meanwhile,Chinese medicine prescriptions for above patients were collected.Eight frequently-used Chinese medicines were selected according to the patient number receiving the medicine,including Ginkgo biloba extract (Ginaton and Shuxuening),Xuesaitong tablet a/injection,Fufang danshen dripping pills,Xueshuan xinmaining tablet,Peiyuan tongnao capsule,Fufang dilong capsule,Naodesheng tablet,and Xinyuan capsule.The randomized controlled trials (RCT) about the effect and safety of aspirin combined with proprietary Chinese medicine in treating ischemic cerebrovascular disease in the elderly patients were retrieved in China National Knowledge Infrastructure (CNKI),Wanfang Database,China Science and Technology Journal Database (CSTJ),PubMed and Excerpta medica database (Embase) taking " aspirin ± above medicines (related English words) " as the key words and the Meta-analysis was processed.Results A total of 14 literatures were enrolled,including 5 literatures about Ginkgo biloba extract,3 literatures about Xuesaitong inject,1 literature about Xuesaitong freeze-dried powder,3 literatures about Fufang danshen dripping pills and 2 literatures about Xueshuan xinmaining tablets.A total of 1 580 patients were entered,with 793 patients receiving combination therapy of aspirin and proprietary Chinese medicine (observation group) and 787 receiving aspirin (control group).The Meta-analysis showed that compared with control group,observation group had better effects on reducing the blood fibrinogen concentration [mean difference (MD) =-0.69,95％ confidence interval(CI):-1.12,-0.26,P =0.002]and improving the nerve function defect [odds ratio (OR) =4.57,95％ CI:3.19,6.54,P ＜ 0.000 01],but with no higher incidence of the adverse drug reaction [OR =1.64,95％ CI =0.81,3.29,P =0.17].Conclusions In the elderly patients with ischemic cerebrovascular disease,aspirin combined with Huoxue Huayu proprietary Chinese medicine can enhance the curative effect,improve the prognosis and raise the life quality,but still need to pay attention to the adverse reactions.
Keywords：Ischemic cerebrovascular diseaseAspirinHuoxue huayu proprietary Chinese medicineMeta-analysis
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 823-827 )