Analysis of thromboelastography outcomes in patients of stable angina pectoris complicated with hyperuricemia
Abstract：Objective To analyze the thromboelastography (TEG) outcomes of patients with stable angina pectoris (SAP) complicated with hyperuricemia (HUA).Methods Four hundred and fifty patients with SAP who underwent percutaneous coronary intervention (PCI) from January 2011 to December 2013 were enrolled and randomly divided into SAP complicated with HUA group (HUA group,129 cases) and without HUA group (non HUA group,321 cases).All the patients received routine examination and TEG test,and the results were compared between the two groups.Results The patients in HUA group had a higher rate of male and smoker,elder age,higher level of body weight,triglyceride,low density lipoprotein-cholestero and high sensitive C-reactive protein compared with those in normal group[80.6％ (104/129) vs 62.6％ (201/321),69.0％ (89/129) vs 44.6％ (143/321),(57±15) vs (52±16) years,(82±19) kg vs (74±21) kg,(2.8±1.2) mmol/L vs (2.0±1.3) mmol/L,(4.0±1.4) mmol/L vs (2.8±1.2) mmol/L,(5.7±1.4) mg/L vs (3.3±1.1) mg/L] (P＜0.05).Both single-factor and multi-factor regression showed that HUA was significantly correlated with adenosine diphosphate (ADP) inhibition rate (r =0.952,0.893,both P ＜0.01).In TEG,statistical differences were found in R value (time of latency from start of test to initial fibrin formation),K value (time taken to achieve amplitude 20 mm),maximum amplitude value and α-angle (the rapidity of fibrin build-up and cross-linking) between HUA group and non HUA goup [(4.9±0.9) minvs (5.2±1.1) rain,(1.4±0.4) min vs (1.9±0.4) min,(58±11)mm vs (52 ± 9) mm,(67 ± 10) ° vs (60 ± 11) °,P ＜ 0.05].ADP inhibition rate was significantly lower in HUA group compared with non-HUA group [(65 ± 21) ％ vs (70 ± 25) ％,P ＜ 0.01];no statistical difference of AA inhibition rate was found between the two groups (P ＞0.05).The incidence of clopidogrel resistance was higher in HUA group than that in non HUA group [24.0％ (31/129) vs 16.2％ (52/321),P ＜ 0.05].Conclusion SAP patients complicated with HUA have more incidences of hypercoagulation states and clopidegrel resistance.
Keywords：Stable angina pectorisHyperuricemiaThromboelastographyArachidonic acidAdenosine diphosphate
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 772-776 )