Effect of Addie injection combined with bleomycin in malignant pleural effusion
Zhong Liping
Pan Yuefen
Shen Junjun
Qi Quan
Liao Haihong
Abstract：Objective To investigate the effect of Addie injection combined with bleomycin in treatment of malignant pleural effusion.Methods Ninety patients of malignant pleural effusion were randomly divided into observation group (45 cases) and control group (45 cases).In all the cases,the pleural effusion was drained by tube thorax.The patients in control group received intrathoracic injection of bleomycin (45-60 mg) +0.9％ sodium chloride + dexamethasone (5 mg) + lidocaine (5 ml) group,the patients in observation group additionally received intrathoracic injection of Addie (50 ml),1 time per week.Four weeks after treatment,the clinical effect,incidence of adverse reactions and Karnofsky performance score (KPS) were evaluated and compared between the two groups.Results After 4 weeks of treatment,the effective rate in observation group reached to 86.7％ (39/ 45),being significantly higher than that in control group 55.6％ (25/45) (P ＜ 0.05);the KPS score and improvement rate of life quality in observation group after treatment were both significantly higher than that in control group [(79 ± 6) scores vs (73 ± 6) scores,75.6％ (34/45) vs 42.2％ (19/45)] (P ＜ 0.05).The incidence of adverse reactions in observation group was significantly lower than that in control group [22.2％ (10/45) vs 68.9％ (31/45)],(P ＜ 0.05).Conclusion Addie injection combined with bleomycin can significantly improve the short-term effect and quality of life with lower incidence of adverse reactions compared with single use of bleomycin in patients of malignant pleural effusion.
Keywords：Addie injectionBleomycinPleural effusion,malignantTreatment outcome
Publication Date：2015-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 664-666 )