Clinical study of saxagliptin in improving insulin resistance in patients with type 2 diabetes
Ye Xiayun
Hou Hongbin
Zhao Yang
Abstract：Objective To evaluate the effects of saxagliptin on insulin resistance in patients with type 2 diabetes.Methods A total of 40 patients with primary diagosed 2 diabetes were enrolled and administrated with saxagliptin (5 mg,1 time/d) for 12 weeks.The changes of fasting plasm glucose (FPG),2 h postprandial blood glucose (2 h PG),glycosylated hemoglobin (HbA1C),homeostasis model assessment β cell function index (HOMA-B),HOMA insulin resistance index (HOMA-IR) and high sensitivity C reactive protein (hs-CRP) were evaluated after 12 weeks of treatment.Results FPG,2 h PG,HbA1c,HOMA-IR,hs-CRP were significantly decreased [(9.2 ± 1.6) mmol/L,(12.7 ± 2.3) mmol/L,(8.1 ± 0.6) ％,3.8 ± 1.1,(31 ± 6) mg/L vs (7.0 ± 0.9)mmol/L,(8.1 ±1.2)mmol/L,(7.1 ±0.6)％,2.6±1.0,(12±6)mg/L,P＜0.01].HOMA-B was significantly increased (27 ± 8 vs 15 ± 6,P ＜ 0.01).Conclusion Saxagliptin can effectively improve insulin resistance in patients with type 2 diabetes,which might be due to its anti-inflammatory function.
Keywords：SaxagliptinDiabetes mellitus,type 2Insulin resistance
Publication Date：2015-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 652-654 )