Effects of rosuvastatin on blood homocysteine, high sensitivity C reactive protein and blood lipid in elderly patients with type 2 diabetes mellitus complicated with carotid artery plaque
Feng Jian
Dong Xinggang
Yu Zhiman
Abstract：Objective To investigate the effects of rosuvastatin on blood homocysteine (Hcy),high-sensitivity C reactive protein (hs-CRP) and blood lipid in the elderly patients with type 2 diabetes mellitus complicated with carotid artery plaque.Methods Ninety-six senile patients with type 2 diabetes complicated with carotid artery plaque were randomly divided into control group (46 cases) receiving conventional treatment and observation group (50 cases) taking oral rosuvastatin (5 mg/d) in addition to conventional treatment.Before and 6 weeks after treatment,the levels of Hcy,hs-CRP,blood glucose,triglycerides (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured and compared between the two groups.Results The levels of blood hs-CRP,TG,TC,LDL-C,Hcy in observation group were significantly lower than those in control group [TC:(4.1 ± 1.2) mmol/L vs (4.6 ± 0.9) mmol/L,LDL-C:(2.2±0.6) mmol/L vs (2.6±0.6) mmol/L,hs-CRP:(12±4) mg/L vs (14±4) mg/L,Hcy:(13±4) μmol/L vs (15 ± 3) μmol/L] (P ＜ 0.05).No significant changes of renal function and routine urine test were found after treatment in both the two groups.One case in observation group had impaired fiver function and recovered after taking oral silymarin for two weeks.Conclusion Rosuvastatin can decrease the levels of blood TG,TC,LDL-C,Hcy and hs-CRP in the elderly patients with type 2 diabetes mellitus complicatred with carotid plaque.
Keywords：Diabetes mellitus,type 2Carotid artery plaqueHomocysteineHigh-sensitivity C reactive proteinRosuvastatin
Publication Date：2015-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 649-651 )