Effect of sofren injection combined with low molecular weight heparin in unstable angina pectoris
Abstract：Objective To observe the clinical efficacy and safety of Soften injection combined with low molecular weight heparin in treatment of unstable angina pectoris (UAP).Methods A total of 100 patients with UAP from January 2012 to May 2014 were enrolled and randomly divided into observation group (50 cases) and control group (50 cases).All the patients received conventional and symptomatic treatment;the patients in observation group were additionally administrated with sofren injection combined with low molecular weight hepa rin.The clinical curative effect,frequency and duration of angina attack,ECG improvement were assessed and compared between two groups 7 days after treatment.Results The clinical efficacy of observation group was significantly higher than that of control group [92.0％ (46/50) vs 72.0％ (36/50),P ＜ 0.05].Before treatment,the frequency and duration of angina attack was (16.7 ± 1.2) times per week and (15.2 ± 2.9) min in observe group;it was (16.8 ± 1.4) times per week and (14.9 ± 3.5) min in control group.After treatment,the angina attack frequency and duration was (3.8 ± 0.5) times per week and (4.5 ± 0.7) min in observe group,which were both significantly lower than those in control group [(7.7 ± 1.2) times per week and (6.9 ± 0.9) min,respectively,both P ＜ 0.05].The improvement rate of ECG in observe group was statistical higher than that in control group [48.0 (24/50) vs 24.0％ (12/50),P ＜ 0.05].Conclusion Sofren injection combined with low molecular weight heparin can effectively and safely improve the angina symptoms and shorten the attack duration in treatment of UAP.
Keywords：Angina,unstableRhodiolaHeparin,low-molecular-weight
Publication Date：2015-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 623-625 )