Effect of eplerenone on ventricular remodeling in patients with acute myocardial infarction
Li Chunhua
Zhao Nian
Liang Xin
Abstract：Objective To investigate the effect of eplerenone on ventricular remodeling in patients with acute myocardial infarction.Methods Totally 120 patients with acute myocardial infarction from January 2008 to October 2012 were enrolled and randomly divided into control group (60 cases) undergoing standard treatment program and observation group (60 cases) administrated with oral eplerenone (40-60 mg/d,at twice or three times) in addition to the standard treatment program.The total efficiency was evaluated.The left ventricular end-diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD),systolic mitral annular displacement,longitudinal fractional shortening and symptom score before and after treatment were assessed and compared between two groups.Results The efficiency of observation group was significantly higher than that of control group [91.7％ (55/60) vs 80.0％ (48/60)] (x2 =7.222,P ＜ 0.05).After treatment,the symptom score,LVEDD,LVESD in treatment group were significantly lower,the systolic mitral annular displacement and longitudinal fractional shortening were significantly higher than those in control group [(12 ±4) scores vs (16 ±4) scores,(51 ±7) mm vs (58±7) mm,(37±5)mmvs (46±5) mm,(13.3±0.5) mm vs (11.0±0.4) mm,(17.4±1.6)％ vs (13.7 ±1.5)％] (all P＜0.05).Conclusion Eplerenone can effectively reduce the infarction ventricular remodeling and improve the ventricular function in patients of acute myocardial.
Keywords：Acute myocardial infarctionEplerenoneVentricular remodeling
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 616-618 )