Protective effect of trimetazidine on myocardial injury induced by percutaneous coronary intervention
Abstract：Objective To observe the protective effect of trimetazidine on myocardial injury induced by percutaneous coronary intervention (PCI).Methods Eighty patients with unstable angina were randomly divided into control group (n =40) and trimetazidine group (n =40).All patients were administrated with aspirin,clopidogrel and other medicines;the patients in trimetazidine group were additionally administrated with oral trimetazidine 3 days before PCI (20 mg/time,3 times/d) till the end of venous sampling.The levels of myocardial injury markers troponin I (cTnI),creatine kinase isoenzyme (CK-MB) and C-reactive protein (CRP) were measured before,6 and 24 h after PCI;the level of interleukin (IL) 6 was detected before and 6 h after PCI.Results There were no significant differences of all indexes between two groups before PCI (all P ＞ 0.05).The serum levels of cTnI,CK-MB,CRP 6 and 24 h after treatment and the level of IL-6 6 h after treatment in trimetazidine group was significantly decreased compared with those in control group [6 h after PCI:cTnI (0.52 ± 0.22) μg/L vs (1.96 ± 1.08) μg/L,CK-MB (52 ± 13) U/L vs (89 ± 19) U/L,CRP (9.6 ± 2.8) mg/L vs (12.7 ± 2.5) mg/L,IL-6 (23 ± 6) ng/L vs (32 ±6) ng/L;24 h after PCI:cTnI (0.44 ±0.26) μ g/L vs (1.98 ± 1.12) μg/L,CK-MB (43 ± 10) U/L vs (72 ± 18)U/L,CRP (14.8 ±5.6)mg/L vs (23.2 ±7.2)mg/L] (all P ＜0.05).Conclusion Trimetazidine can reduce the levels of myocardial injury markers and inflammatory cytokines after PCI and has myocardial protective effect.
Keywords：Percutaneous coronary interventionTrimetazidineMyocardial injuryInflammatory cytokines
Publication Date：2015-05-02
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 609-611 )