Change of serum insulin like growth factor 1 in diabetic nephropathy patients
Jin Xiuping
Zhao Lei
Wang Ying
Ding Zhu
Abstract：Objective To observe the changes of insulin like growth factor 1 (IGF-1) in serum of patients with different degrees of diabetic nephropathy.Methods Totally 30 healthy control (control group) and 120 patients with type 2 diabetes were enrolled.According to the urinary albumin excretion rate,the patients with type 2 diabetes were divided into 4 groups:type 2 diabetes non-nephropathy group (DM group,31 cases),early diabetic nephropathy group (DN1 group 35 cases),clinical diabetic nephropathy group (DN2 group,32 cases) and end stage diabetic nephropathy group (DN3 group,22 cases).The IGF-1 concentration in serum was measured,the urine trace albumin was determined by radioimmunoassay method and the urinary albumin excretion rate (UAER) was then calculated.The glycosylated hemoglobin (HbA1 c),fasting plasma glucose (FPG),growth hormone (GH),blood lipid,blood pressure and glomerular filtration rate (GFR) were measured and compared between the two groups.Results ① The level of serum IGF-1 in DN1 group was higher than that in DM group and in control group [(228 ±30) μg/L vs (192 ±41),(198 ±20) μg/L] (P ＜0.05) ; DN2 group was higher than DN1 group [(364 ± 26) μg/L vs (228 ± 30) μg/L] (P ＜ 0.05) ; DN3 group was the highest [(388 ± 30) μg/L].The GH level had no significant differences among all the five groups (all P ＞ 0.05).②The level of UAER,HbA1c and FPG in type 2 diabetes groups were all significantly higher than those in control group,and in diabetic nephropathy groups were all higher than those in DM group(all P ＞ 0.05).The GFR level in DM group was lower than that in control group[(147 ±20)ml/min vs (100 ± 18) ml/min,P ＜0.05],and the GFR level in DN1,DN2 and DN3 group decreased in sequence [(140 ± 24),(68 ± 10),(10 ± 3) ml] with significantly differences (P ＜ 0.05),all being lower than that in DM group (all P ＜ 0.05).③The level of total cholesterol (TC),triglyceride (TG) and systolic blood pressure in type 2 diabetes groups were all significantly higher than those in control group,and in diabetic nephropathy groups were all higher than those in DM group (all P ＜ 0.05).④Serum level of IGF 1 was positively correlated with UAER,HbA1c,FPG,TC,TG,systolic blood pressure and duration; it was negatively correlated with GFR.Conclusions Increase of serum IGF-1 level is associated with the severity of diabetic nephropathy.
Keywords：Insulin like growth factor 1Diabetic nephropathyUrinary albumin excretion rate
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 355-359 )