Antiplatelet effect of preoperative panaxtriol saponins on off-pump coronary bypass grafting
Abstract：Objective To explore the antiplatelet effect of preoperative panaxtriol saponins among patients who underwent off-pump coronary artery bypass grafting (OPCAB).Methods A total of 273 patients were divided into intervention group (134 cases) that had panaxtriol saponins for 5-7 days before operation plus conventional treatment; control group had conventional treatment.Results The drainage volume on the first and second day after operation in the two groups had no statistical difference (P =0.646,0.411).The platelet aggregation rate (arachidonic acid,adenosine diphosphate) of the two groups was significantly different[arachidonic acid:(46 ± 8) ％ vs (58 ± 8) ％,adenosine diphosphate:(61 ± 5) ％ vs (67 ± 5) ％,P =0.000].The thoracotomy rate of the two groups had no statistical difference (P =0.577) and the incidence of perioperative myocardial infarction of the two groups had significant differences [0.7％ (1/134)vs 5.8％(8/139),P=0.031].Conclusions Preoperative administration of panaxtriol saponins can obviously inhibit the perioperative platelet aggregation and reduce incidence of perioperative myocardial infarction without increasing perioperative drainage in OPCAB.
Keywords：Panaxtriol saponinsAntiplateletCoronary artery bypass grafting
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 309-311 )