Short term efficacy and safety of antiplatelet of ticagrelor treating multivessel acute coronary syndrome patients with percutaneous coronary intervention
Xia Jinggang
Qu Yang
Hu Shaodong
Xu Ji
Yin Chunlin
Xu Dong
Abstract：Objective To evaluate the safety and efficacy of antiplatelet therapy of ticagrelor in treatment of multivessel acute coronary syndrome patients who received primary percutaneous coronary intervention (PCI).Methods Totally 120 patients of acute coronary syndrome with multivessel disease who received PCI were randomly divided into ticagrelor group (n =60,preoperative 180 mg loadin,90 mg after operation,two times per day) and clopidogrel group (n =60,preoperative 600 mg loading,75 mg after operation,once per day).Baseline data,coronary artery disease characteristics,platelet count,adenosine diphosphate induced platelet inhibition rate before and after 5 days of treatment,major adverse cardiovascular events(MACE) and adverse reactions including bleeding complications were observed.Results The differences of baseline data,coronary artery disease characteristics,platelet count before and after 5 days of treatrment between the two groups had no statistical significance (P ＞ 0.05).Adenosine diphosphate induced platelet inhibition rate after 5 days of treatment in ticagrelor group was significantly higher than that in clopidogrel group [(81 ± 10)％ vs (76 ± 12)％,P ＜ 0.05].Two groups of patients were followed up for 3 months.Eight MACEs (13.3％) occurred in clopidogrel group; 5 MACEs (8.3％) occurred in ticagrelor group.The incidence of MACE had no statistical differences (P ＞ 0.05).The two groups had no statistically significant differences in adverse reactions (P ＞ 0.05).Conclusions Antiplatelet therapy of ticagrelor treating acute coronary syndrome patients with multivessel disease who received PCI is good and safe.
Keywords：Acute coronary syndromeTicagrelorMultivessel diseasePercutaneous coronary intervention
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 289-293 )