Relation among different serum uric acid levels, glomerular filtration rate and urinary albumin execretion in patients with type 2 diabetes mellitus
Han Rongfeng
Jiang Xia
Abstract：Objective To study the relation among glomerular filtration rate (GFR),urinary albumin execretion and serum uric acid (UA) in patients with type 2 diabetes mellitus.Methods MDRD equation was used to calculate the GFR.A total of 686 patients with type 2 diabetes mellitus were divided into 3 groups according to their GFR.Group A GFR ≥ 90 ml/(min · 1.73 m2),191 cases ; group B:60 ml/(min · 1.73 m2) ≤ GFR ＜90 ml/(min · 1.73 m2),383 cases ; group C:GFR ＜ 60 ml/(min · 1.73 m2),112 cases and clinical features were analyzed.The patients were categorized into four groups based on quartiles of the serum uric acid level to evaluate the diversity and the correlation of GFR and 24h urinary albumin execretion (24h-UAE).UA ＜ 214.7 μmol/L group,171 cases; UA 214.7-271.6 μmol/L geoup,172 cases; UA 271.6-329.4 μmol/L group,172 cases; UA ＞329.4 μmol/L group,171 cases.Results The age,history,creatinine,UA,triglycerides and 24h-UAE were significantly different among group A,B,C segregated by GFR [age:(53 ± 13),(61 ± 11),(68 ± 9)years old,history:(6.0 ±2.3),(7.9 ±3.3),(14.0 ±4.5) years,creatinine:(57 ±9),(62 ± 16),(137 ± 83) μmol/L,UA:(258 ± 83),(282 ± 80),(345 ± 96) μ mol/L,triglycerides:(5.0 ± 1.1),(5.3 ± 1.2),(5.7 ± 1.4) mmol/L,ln (mALB/24 h):(1.9 ± 0.8),(2.0 ± 0.6),(2.6 ± 0.9)] (P ＜ 0.01 or P ＜ 0.05).Pearson correlation showed that serum uric acid was negatively correlated with GFR (r =-0.248,P ＜0.01) ; serum uric acid was positively correlated with 24h-UAE (r =0.254,P ＜ 0.01) ;GFR was negatively correlated with 24h-UAE (r =-0.352,P ＜0.01).Logistic regression analysis suggested that UA,age,history triglycerides were the independent risk factors for renal insufficiency(OR =1.013,OR =1.093,OR =1.097,OR =1.369,P ＜0.01 or P ＜0.05) ;UA,age,history and triglycerides were the independent risk factors for abnormal albuminuria (OR =1.004,OR =1.029,OR =1.073,all P ＜ 0.05).Conclusions There is an association among glomerular filtration rate,urinary albumin execretion and serum UA in patients with type 2 diabetes mellitus.Serum UA level is one of the independent risk factors for abnormal albuminuria and renal insufficiency.
Keywords：Diabetes mellitus,type 2Uric acidGlomerular filtration rateUrinary albumin
Publication Date：2015-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 200-203 )