Effect of probucol on serum resistin and blood lipid profile in patients with acute cerebral infarction

Zhang Peng; Nie Shuhui; Xue Linghui

doi:10.3760/cma.j.issn.1673-4777.2015.02.013

Abstract：Objective To investigate the effect of probucol on the levels of serum resistin and blood lipid in patients with acute cerebral infarction.Methods Totally 102 patients with acute cerebral infarction were collected from April 2012 to April 2013.The patients were randomly divided into two groups:conventional treatment group(51 cases) and combined treatment group (51 cases).At the first day and after two weeks,the fasting venous blood samples were collected for measuring serum resistin and total cholesterol,triacylglycerol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol.At 7 d and 14 d,curative effects were evaluated by standard scale of clinical neurological deficit.Results After the treatment,the level of serum resistin in combined treatment group[(17 ± 9)mg/L] was lower than that before treatment [(24 ± 9)mg/L] and that in the conventional treatment group [(23 ± 9)mg/L] ; the level of total cholesterol [(4.0 ± 1.0)mmol/L] was lower than that before treatment[(5.0 ± 1.0)mmol/L] ; the level of LDL-C [(2.3 ± 0.8)mmol/L] was lower than that before treatment[(3.3 ±0.8) mmol/L] and that in the conventional treatment group[(2.8 ± 1.0) mmol/L] ; neurological function score [(8.0 ± 3.2) points] was below than that before treatment [(25.0 ± 2.9) points] and that in routine treatment group[(13.2 ± 2.5) points] ; the differences were statistically significant (all P ＜ 0.05).Conclusion The treatment of probucol combining with statins can improve the level of serum resistin and blood lipid profile of patients with acute cerebral infarction.