A Meta-analysis of salmeterol fluticasone combined with montelukast in the treatment of asthma in children
Xu Shuwen
Li Yan
Zheng Hongyun
Dai Wen
Abstract：Objective To assess the efficacy of salmeterol fluticasone combined with montelukast in the treatment of asthma in children.Methods Database such as PubMed,Cochrane Library,EMbase,China knowledge Resource Integrated Database,CBMdise and Chinese Journal Literature Database were searched.Results Eleven literatures were reviewed including 410 cases receiving salmeterol fluticasone combined with montelukast and 378 cases receiving salmeterol fluticasone alone.Meta analysis revealed that peak expiratory flow [weighted mean difference (WMD) =6.53,95 ％ confidence interval (CI) (2.71,10.36),P ＜ 0.01],forced expiratory volume in the first second [WMD =7.28,95％ CI (3.30,11.26),P ＜ 0.01],symptom score [WMD =-0.25,95 ％ CI(-0.34,-0.17),P ＜ 0.01],clinical control rate [odds ratio (OR) =1.76,95 ％ CI (1.12,2.75),P =0.01] and effective rate [OR =4.32,95 ％ CI(1.63,11.45),P ＜ 0.01] had statistical differences.Conclusion The efficacy of salmeterol fluticasone combined with montelukast is superior to salmeterol fluticasone alone in the treatment of asthma in children.
Keywords：Salmeterol fluticasoneMontelukastAsthma
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 172-176 )