The clinical significance of plasma fibrinogen monitoring in elderly patients with chronic obstructive pulmonary disease in acute exacerbation period
Wang Yao
Zhou Wei
Abstract：Objective To explore the clinical significance of plasma fibrinogen(Fib) monitoring in elderly patients with chronic obstructive pulmonary disease during acute exacerbation period(AECOPD).Methods Totally 45 AECOPD people(the observation group) and 55 COPD people(the control group) were completely random selected.The general data,4 coagulation parameters [prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time(TT),Fib] within 24 hours of admission,D-dimer and C-reactive protein (CRP) were collected and compared between 2 groups.Results In the observation group,TT was longer than that in the control group ; the difference was statistical significance [(12.0 ± 2.3) s vs (11.1 ± 1.1) s] (P ＜ 0.05).Fib and CRP levels were higher than those in the control group ; the difference was statistical significant [(3.9 ± 1.1) g/L vs (3.4 ±0.7) g/L,(33.3 ± 26.6) mg/L vs (4.4 ± 2.2) mg/L] (P ＜ 0.01) ; there was no difference between the two groups regarding PT,APTT and D-dimer(P ＞ 0.05).Conclusions Elderly patients with AECOPD fibrinogen levels are significantly increased,which suggests that hypercoagulable states; Fib can be used as an indicator of AECOPD inflammation and disease monitoring.
Keywords：Chronic obstructive pulmonary diseaseAcute exacerbation periodFibrinogenD-dimerCoagulation function
Publication Date：2015-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 169-171 )