Correlation analysis of matrix metalloproteinase-9 expression and coronary artery disease in acute coronary syndrome patients
Ma Jian
Zhang Yong
Tian Caixia
Abstract：Objective To investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression and coronary artery disease in acute coronary syndrome(ACS) patients.Methods Totally 80 acute coronary syndrome patients from August 2011 to December 2013 in Hubei Medical College Affiliated Dongfeng Hospital were selected for the observation group (45 cases of unstable angina,35 cases of acute myocardial infarction),80 no-acute coronary syndrome patients were selected for the control group.The clinical data and biochemical data of two groups were analyzed retrospectively.Results The serum MMP-9 values in observation group was significantly higher than that in control group [(125 ± 14) μg/L vs (87 ± 14) μg/L,P ＜0.05],at the same time the serum MMP-9 values in patients with acute myocardial infarction were significantly higher than those in patients with stable angina [(146 ± 14) μg/L vs (111 ± 14) μg/L,P ＜0.05].Multivariate logistic regression analysis showed that the odds ratio of matrix MMP-9 was 1.982,the 95％ CI were 1.029-2.837,P ＜0.05 ; odds ratio of triglyceride was 11.870,95％ CI were 2.819-14.822,P ＜0.05 ; the odds ratio of total cholesterol was 3.782,the 95％ CI were 1.673-8.993,P ＜0.05.Conclusion ACS is associated with increased MMP-9 which is also correlated with severity of coronary artery disease.
Keywords：Acute coronary syndromeCoronary artery diseaseMatrix metalloproteinase-9Correlation
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 150-152 )