Effect of Shouwuyizhi capsule on the ultrastructure of brain tissue vascular dementia model rats
Yang Xiaoni
Li Changsheng
Chen Chao
Cheng Guangqing
Abstract：Objective To investigate the effect of Shouwuyizhi (SWYZ) capsule on the ultratructure of brain tissue in experimental rats with vascular cognitive impairment (VCI).Methods The VCI model rats were established with MCAO method.All experimental rats were divided into Shouwuyizhi group,Naofukang group,model group and sham operation group.After 4 weeks,the rats cerebral histomorphological change was observed.Results In the sham operation group,the nucleus of hippocampal neurons was clear,organelles were abundant and had clear nuclei structure in 10 rats.In the model group,hippocampal pyramidal cells were missed with swollen mitochondria and perivascular edema in 9 rats.In the Naofukang group,hippocampus nerve cells' membrane structure was relatively clear; some mitochondria presented flocculent degeneration and myelin structure was clear in 7 rats.In the Shouwuyizhi group,the loss of pyramidal cells was reduced; organelles were basically normal; perivascular edema was significantly relieved in 9 rats.Conclusion SWYZ capsule can significantly improve the VCI rat neuronal injury.
Keywords：Vascular cognitive impairmentShouwuyizhi capsuleAnimal experiment
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 82-84 )