Correlation between carotid intima-media thickness and plaque stability in metabolic syndrome
Miao Ying
Hu Rong
Abstract：Objective To study the correlation between carotid artery intima-media thickness (IMT) and plaque stability in metabolic syndrome (MS).Methods From March 2011 to December 2012 at Beijing Anzhen Hospital,carotid of 2 292 patients was examined using ultrasonography ; carotid intima-media thickness and plaque detection rate were collected.The patients were divided into none-plaque group (1 582 cases) and plaque group (710 cases) ; based on the results of carotid plaque ultrasound echo characteristics,plaque group was divided into subgroups of stable (301 cases) plaque and unstable plaque (425 cases).Results IMT of overweight and/or obesity (662 cases),diabetes (713 cases),hypertension (742cases) and dyslipidemia (624 cases) was significantly higher than that of no overweight / or obesity (737 cases),no diabetes (686cases),no hypertension (657 cases) and no dyslipidemia(775cases) [(1.36 ± 0.35),(1.49±0.41),(1.43 ± 0.38),(1.51±0.48)mmvs(1.16 ± 0.24),(1.18 ± 0.22),(1.09 ± 0.19),(1.05 ± 0.13) mm,P＜0.05].Dyslipidemiacarotid detection rate was 55.1％ (365/662),58.6％ (418/713),60.5％ (449/742),68.1％ (425/624)respectively.Carotid detection rate was 46.8％ (345/737),42.6％ (292/686),39.7％ (261/657) and 36.8％ (285/775) (P ＜ 0.05).With 1,2,3 MS components,IMT was (1.31 ± 0.24) mm,(1.46 ± 0.35) mm and (1.66±0.39) mm; carotid artery plaque detection rate was 38.2％ (233/610),54.7％ (223/408) and 66.7％ (254/381).Systolic blood pressure (OR =3.212,95％ CI:1.542-5.295),fasting plasma glucose (FPG) (OR =3.082,95％ CI:1.416-4.985),low-density lipoprotein cholesterol (LDL-C) (OR =3.087,95 ％ CI:1.654-7.395) and metabolic syndrome (OR =4.624,95％ CI:1.654-7.295) were independent risk factors of carotid artery plaque formation (P ＜ 0.05).High-density lipoprotein cholesterol (HDL-C) (OR =0.735,95 ％ CI:0.449-0.952) was a protective factor of carotid plaque (P ＜ 0.05).FPG(OR =2.156,95 ％ CI:1.424-5.249),TC (OR =1.895,95 ％ CI:1.169-3.195),MS(OR =3.652,95％ CI:1.752-8.985) and unstable carotid artery plaques were independent risk factors (P ＜ 0.05) ; HDL-C (OR =0.758,95％ CI:0.424-0.946) was a protective factor (P ＜ 0.05).Conclusions MS and MS components increase carotid atherosclerosis risk and they are closely related to the IMT thickening,plaque formation and plaque unstable ; carotid ultrasonography contributes to early prevention of cardiovascular events.
Keywords：Metabolic syndromeCarotid artery intima-media thicknessCarotid atherosclerosisCarotid artery plaque
Publication Date：2015-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 66-70 )