Study on the relation between blood pressure variability and severity of coronary artery lesion in hypertension patients
Li Jing
Mi Shuhua
Jia Shujie
Zhou Yun
Wang Yang
Abstract：Objective To discuss the relation between blood pressure variability and severity of coronary artery lesion.Methods A total of 124 hypertension patients had coronary artery angiography.The degree of coronary artery stenosis and the coronary lesions integral (CAS) were analyzed.According to the coronary artery angiography results,the patients were divided into four groups:group A (0-4),group B (＞ 4-29),group C (＞ 29-63) and group D(＞ 63).All patients had 24 hours ambulatory blood pressure monitory.The blood pressure variability including 24 h systolic blood pressure coefficient of variation (24 h SCV),day systolic blood pressure coefficient of variation (dSCV),night systolic blood pressure coefficient of variation (nSCV),24 h diastolic blood pressure coefficient of variation (24 h DCV),day diastolic blood pressure coefficient of variation (dDCV) and night diastolic blood pressure coefficient of variation (nDCV) were analyzed.The correlation between the blood pressure variability and severity of coronary artery lesion were analyzed.Results The levels of 24 h SCV,dSCV and nSCV increased with the degree of CAS[24 h SCV of four groups were (11.7 ± 2.3),(13.8 ± 2.1),(14.9 ± 3.3) and (16.5 ± 3.9) ; dSCV of four groups were (13.2 ± 2.7),(15.0 ± 2.7),(16.9 ± 3.8) and (18.8 ± 4.3) ; nSCV of four groups were(10 ±4),(13 ±4),(14 ± 3) and(15 ± 3)] ; the differences of same index in four groups were statistically significant (P ＜ 0.05).The levels of 24 h DCV in group B,C,D were significantly higher than those in the group A ; the difference were statistically significant [(9.2 ± 3.0),(9.4 ± 2.7),(9.4 ± 2.9) vs (8.6 ± 2.5),P ＜ 0.05].Compared CAS with Spearman,CAS was positively correlated with 24 h SCV,dSCV and nSCV (r =0.493,0.465,0.390,P ＜0.05).By the multiple linear regression between CAS and paramenters,CAS was independently correlated with 24 h SCV and dSCV (P ＜ 0.01).Conclusions The levels of blood pressure variability increasewith the degree of CAS.24 h SCV and dSCV are independent risks factor for CAS.
Keywords：HypertensionBlood pressure variabilityCoefficient of variabilityCoronary artery disease
Publication Date：2015-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 50-54 )