Relationship between plasma B-type natriuretic peptide and Gensini score in patients with acute coronary syndrome

Zheng Hong; Mi Shuhua; Zhao Quanming; Tian Lei; Jia Shujie; Yang Hongxia

doi:10.3760/cma.j.issn.1673-4777.2015.01.012

Abstract：Objective To explore the relation between plasma B-type natriuretic peptide (BNP) and Gensini score in patients with acute coronary syndrome(ACS).Methods There were 309 patients who were diagnosed of ACS (66 patients with acute myocardial infarction,243 patients with unstable angina) by coronary artery angiography.70 cases with angiographically normal coronary arteries were as control group.Plasma BNP levels were detected and calculated by Gensini score.Patients was divided based on the coronary lesions.The patients with ACS were divided into one-artery lesion group (132 cases),two-artery lesion group (115 cases) and three-artery lesion group (62 cases).The patients with ACS were also divided into Gensini score ＜ 20 group (68 cases),Gensini score 20-40 group (128 cases) and Gensini score ＞40 group (113 cases).The relation between the plasma B-type natriuretic peptide and Gensini score were analyzed.Results Serum level of BNP was significantly higher in patients with ACS than in the control group [120.0 (54.6,226.7) ng/L vs 18.0(14.0,28.6) ng/L,P ＜ 0.01].Serum levels of BNP in three-artery lesion group were significantly higher than those in the two-artery lesion group and one-artery lesion group [(269 ± 197) ng/L vs (159 ± 88),(82 ± 54) ng/L,P ＜ 0.01].Serum levels of BNP in Gensini score ＞40 group was significantly higher than that in the Gensini score 20-40 group and Gensini score ＜20 group[(214 ± 126) ng/L vs (122 ± 80),(88 ±56) ng/L,P ＜0.01].Correlation test showed that level of serum BNP and Gensini score were correlated (r =0.534,P ＜ 0.01).Conclusion Plasma levels of BNP are closely related with the severity of coronary artery lesions,and detection of plasma BNP levels can reflect the severity of coronary artery disease.