The study of different human papilloma virus sampling methods for cervical cancer screening

Zhang Haimeng; Li Li; Sui Shuang; Mayinuer Niyazi

doi:10.3760/cma.j.issn.1673-4777.2015.01.010

Abstract：Objective To explore the human papilloma virus (HPV) sampling methods to reduce the incidence and mortality of cervical cancer in rural areas and among minority population.Methods A cross-sectional study with the entire cluster sampling method for cervical cancer screening in Yutian County between 2006 and 2007 was conducted.All women with an active sex life were 16-59-years old.With consented epidemiological survey of cervical cancer,eligible women were examined by HPV test and clinical examinations.HPV sampling way was divided into two parts:HPV self-sampling and HPV physician-sampling (vulva,vaginal lower segment,the upper vagina and cervix).Exfoliated cells were collected for HPV test by using the second-generation hybrid capture (HC2).The women with positive results accepted colposcopy and cervical biopsy.Results A total of 883 Uygur women were included in this study.The sensitivity of HPV physician-sampling and self-sampling was 94.12％ (91.74％,96.50％) and 88.24％ (87.56％,88.92％).The specificity of HPV physician-sampling and self-sampling was 94.46％ (91.80％,97.12％) and 93.84％ (91.66％,96.02％).There was no statistical significance in sensitivity and specificity between the two sampling ways.The sensitivity of cervical sampling (94.12％) was higher than that of vulva sampling (47.06％) (46.94％,47.18％),but there was no statistical difference between cervical sampling and upper vaginal sampling (88.24％) (87.56％,88.92％) ; vaginal lower segment sampling was 70.59％ (70.42％,70.76％).The positive predicting values and negative predicting values of cervical sampling were higher than those of vulva sampling.Conclusions HPV self sampling can replace physician sampling.Cervix is the optimistic site for HPV sampling.