The curative effect and adverse reactions of analgesics in patients with liver tumors after transcather arterial chemoembolization

Han Chunshan; Han Lingmin; Yu Xiaoli

doi:10.3760/cma.j.issn.1673-4777.2015.01.004

Abstract：Objective To evaluate the efficacy and main side effects of different analgesics in patients with liver tumors after transcather arterial chemoembolization.Methods A total of 98 patients with moderate pain of liver after embolization were randomly divided into group A,group B and group C.Patients in group A (n =33) were treated with oxycodone hydrochloride controlled-release tablets,while the patients in group B (n =27) received fentanyl transdermal,group C(n =38) accepted paracetamol and dihydrocodeine tablets.In the addition,morphine injections were used to deal with the outbreak of pain during this research.The observation indexes were recorded,including the mean time for onset,up-to-standard of analgesic effect,rate of pain relief with single drug,the average dosage of morphine and side effect.Results The mean time of onset of analgesic effects was (62 ± 25) minutes (group A),(531 ± 227) minutes (group B) and (41 ± 20)minutes (group C) respectively; the mean time ofmeeting analgesic standards was (38 ± 14) hours (group A),(49 ± 15) hours (group B) and (28 ± 6) hours (group C) ; there were significant differences among three groups (P ＜ 0.01).The pain relief rate with single drug was 100.0％ (33/33) (group A),66.7％ (18/27) (group B) and 86.8％ (33/38) (group C) ; meanwhile in each group it was (6 ±5)mg (group A),(13 ±7)mg (group B) and (11 ±9)mg (group C) morphine injection.The incidences of adverse reactions including constipation and drowsiness were significantly different among group A,B and C.[66.7％ (22/33),37.0％ (10/27) vs 5.3％ (2/38) ; 9.1％ (3/33),75.9％ (7/27) vs 0.0％,P ＜ 0.05] Conclusion Oxycodone hydrochloride tablets is effective for liver tumors after embolization.