Relation between ultrasound and immune-histochemical findings of breast cancer

Liu Haifang; Gao Yang; Jiang Nan; Qiao Hua; Yong Qiang

doi:10.3760/cma.j.issn.1673-4777.2015.01.001

Abstract：Objective To investigate the ultrasound burr on the edge of the breast cancer,tiny calcification and biological indicators such as estrogen receptor (ER),progesterone receptor (PR),c-erbB-2 and p53; to provide guidance for preoperative adjuvant therapy for breast cancer and prognosis judgments.Methods Totally 45 cases pathologically diagnosed of breast cancer after operation were enrolled; ER,PR,c-erbB-2 cases and p53 expression were detected ; the relation between the ultrasonic manifestations and molecular biological indicator were analyzed.Results Level of ER and PR was significantly higher in mass with edge burr of lump than that in mass without edge burr[85.3％ (29/34) vs 36.4％ (4/11),P =0.005 ; 85.3％ (29/34) vs 45.4％ (5/11),P =0.008] ; the positive rate of c-erbB-2 and p53 in mass with edge burr of lump and in mass without edge burr did not have statistically significant difference [58.8％ (20/34) vs 27.3％ (3/11),P =0.141 ; 58.8％ (20/34) vs 18.2％ (2/11),P =0.072].The level of c-erbB-2 and p53 was significantly higher in tumor with micro calcifications than that in tumor without micro calcifications [94.4％ (17/18) vs 22.2％ (6/27),P =0.005 ; 88.9％ (16/18) vs 22.2％ (6/27),P =0.000].The positive expression rate of ER and PR in tumors with and without micro calcifications had no statistically significant difference[72.2％ (13/18) vs 74.1％ (20/27),P =0.953; 83.3％ (15/18)vs 70.4％ (19/27),P =0.534].Conclusions Edge burr sign and micro calcification sign for breast cancer in ultrosound imaging can be used to predict the expression level of certain immunohistochemical factors (ER,PR,c-erbB-2,p53).The biologic behavior of breast cancer can be predicted according to the ultrasonographic features,which can provide guide for early clinical treatment.