Comparison of clinical effects of letrozole and clomiphene citrate on polycystic ovary syndrome inertility
Guo Caifeng
Lin Lan
Lin Shanying
Abstract：Objective To compare the effect of induced ovulation and pregnancy results of letrozole(LE) and clomiphene citrate(CC) treating polycystic ovary syndrome (PCOS).Methods Sixty-seven cases of PCOS patients were randomly divided into two groups,with 34 cases in LE group and 33 cases in CC group.The patients were treated with LE 5 mg and CC 50 mg respectively in the menstrual cycle of 3-7d for five days.The effects of LE and CC on follicular development,endometrial,sex hormone level and pregnancy outcome were observed.Results The mature follicle number and average diameter in CC group were higher than those in LE group [(2.2 ±1.5) vs (1.4 ± 1.1) ; (25 ± 6) mm vs (20 ± 5) mm],while the thickness of endometrium and uterine cavity volume in CC group were less than those in LE group [(7.6 ± 2.0) mm vs (9.5 ± 1.8) mm ; (3.5 ± 1.8) ml vs (5.4 ±1.2) ml] ; the differences were statistically significant(P ＜ 0.05).Serum estradiol levels on the day of HCG injection in LE group were less than those in the CC group[(869 ± 131) pmol/L vs (1 248 ± 112)pmol/L],but the LH peak was higher than that in CC group[(14.3 ± 1.5) d vs (12.5 ± 2.1) d] ; the difference was statistically significant (P ＜ 0.05).The ovulation rate,incidence of luteinized unrup tured follicle syndrome (LUFS) and ovarian hyperstimulation syndrome (OHSS) in LE group were lower than those in CC group [64.7％ (44/68) vs 80.0％ (56/70) ; 2.3 ％ (1/44) vs 14.3 ％ (8/56) ;0.0％ (0/44) vs 10.7 ％ (6/56)],but the biochemical pregnancy rate and the clinical pregnancy rate in LE group were significantly higher than those in CC group [50.0％ (22/44) vs 32.1％ (17/56) ;47.7％ (21/44) vs 28.6％ (16/56)] ; the difference had statistical significance (P ＜ 0.05).Conclusion Although the ovulation effect of CC is better than that of LE,the LE has the higher pregnancy rate,lower rate of multiple pregnancy and less incidence of LUFS and OHSS.
Keywords：Polycystic ovary syndromeLetrozoleClomiphene citrateInfertility
Publication Date：2014-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1801-1805 )