Dose effect of 5-aminolevulinic acid photodynamic therapy on male urethra condyloma acuminatum
Duan Yan
Li Ruiya
Zeng Kang
Sha Na
Wang Jian
Abstract：Objective To study the different dosage effect of 5-aminolevulinic acid photodynamic therapy on male urethra condyloma acuminatum.Methods Totally 64 male urethra condyloma acuminatum patients were divided into 2 groups:normal dosage group and half-dosage group.34 patients in the normal dosage group were given 118 mg ALA and 30 patients in the half-dosage group were given 54 mg ALA.The clinical effect,the relapse rate and the untoward reaction were analyzed after 6 months of treatment.Results The effective rate was 100.0％ (34/34) in the normal dosage group.There were 4 relapse patients after 6 months of treatment; the relapse rate was 12.5％ in the normal group,while the effective rate was 96.7％ (29/30) in the half-dosage group of 30 patients treated in same method ; there were 11 relapse patient after 6 months of treatment and the relapse rate was 42.3％.27 patients had the adverse reactions in both normal and half-dosage group.There was no significant difference in effective rate(P ＞0.05),while there was significant difference (P ＜ 0.05) in relapse rate between normal and half-dosage group.Conclusion The normal dosage should be used during the treatment of male urethra condyloma acuminatum with the ALA-PDT method,which can decrease the relapse rate and has a good correlation between dosage and effects.
Keywords：Condyloma acuminatum5-aminolevalinic acid-photodynamic therapyMale urethraDose effect relationship
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1794-1796 )