Efficacy and safety of combining rociverine tablets with Suoquan capsule in treatment of overactive bladder
Liu Cheng
Mu Jiagui
Liu Duo
Liu Xuejun
Ren Yansheng
Zhu Dongsheng
Abstract：Objective To assess the efficacy and safety of combining Rociverine Tablets with Suoquan capsule in treatment of patients with overactive bladder(OAB).Methods Totally 126 cases of overactive bladder were collected to research and were randomly divided into four groups.Patients in A group were administrated with Rociverine Tablets at 10mg and Suoquan capsule at 1.8g three times a day for 4 weeks.Patients in B group were administrated only with Rociverine Tablets for 4 weeks.Patients in C group were administrated only with Suoquan capsule for 4 weeks.All patients had the bladder training.The efficacy and safety of treatment were assessed before and after treatment in the subjective outcome measure of OABSS and the objective outcome measures including daily frequency of micturition,urgency,urgency incontinence,nocturia and avoiding volumes.Results The subjective outcome measure and objective outcome measures in the A group before-and after-treatment:(9.5 ± 2.1)and (2.4 ± 1.0) for OABSS,(13.6 ± 3.8) and (7.2 ± 1.3) for frequency of micturition,(7.7 ± 2.7) and (2.4 ± 1.2) for frequency of urgency,(3.5 ± 1.4) and (0.8 ± 0.3) for frequency of nocturia,(4.1 ± 2.1) and (1.0 ± 0.3)for frequency of urgency incontinence,(124 ± 28) and (280 ± 36) ml for voiding volumes.These data in the B group were(9.7 ± 1.8)and(5.4± 1.9),(13.9 ±3.6)and(8.8 ± 1.4),(7.6±2.5)and(4.4 ± 1.4),(4.2 ± 1.8)and (1.8 ±0.4),(3.6± 1.3)and(1.6 ±0.4),(122 ±29)and(210 ±38).These in the C group were (9.6 ±2.0) and (5.3 ±1.8),(13.8 ±3.7) and (8.7±1.2),(7.7±2.4) and (4.3±1.3),(4.3±2.1) and (1.7 ± 0.5),(3.6±1.5)and(2.0±0.2),(124±27)and(212±36).These in the D group were (9.2±1.9) and (8.4 ±1.8),(13.5 ±3.4) and (11.2 ±2.2),(7.6 ±2.6) and (6.4±2.1),(4.3 ±2.0) and (3.3 ±0.4),(3.5 ± 1.3) and (2.8 ± 0.3),(125 ± 28) and(161 ± 38).There wre significant differences in subjective and objective outcome measures of patients in each group before and after treatment (P ＜ 0.05).Moreover,compared with D groups,A,B and C groups all had significant differences in subjective and Objective outcome measures of patients at the end of treatments(P ＜ 0.05).There were significant differences in subjective and Objective outcome measures of patients between A and B groups.The incidences of adverse events of A,B and C groups were 8.8％ (3/34),21.8％ (7/32) and 9.3％ (3/32) respectively.There were significant differences in the incidences of adverse events between A group and B group (P ＜ 0.05).There were no significant differences in the incidences of adverse events between A group and C group (P ＞ 0.05).No severe adverse events happened in four groups.Conclusion Combining Rociverine Tablets with Suoquan capsule in treatment of patients with overactive bladder can significantly improve the clinical efficiency.
Keywords：Overactive bladderRociverineSuoquan capsule
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1790-1793 )