Parecoxib prevents post laparoscopic operative emergence agitation in adults: a Meta analysis
Zhang Yuan
Xia Zhongyuan
Zhou Xianjin
Abstract：Objective To provide a systematic review of parecoxib preventing post-laparoscopic-operative emergence agitation in adults plus reliable clinical evidences for an ideal pharmacological management of emergence agitation.Methods A comprehensive literature search was conducted to identify randomized controlled trials that focused on parecoxib preventing emergence agitation post-laparoscopic-operative in adults.The databases included PubMed,EBSCO,Springer,Ovid,EMbase,Cochrane Library,Web of Science and the China Nation Knowledge Infrastructure,Weipu Data Base and Wanfang Data Base.Literature screening had inclusive and exclusive criteria; data extracting,quality assessment and the incidence of emergence agitation,nausea and vomiting were analyzed.Results Nine articles had a total of 580 patients,including 300 cases of parecoxib and 280 cases of saline.The results of meta-analyses showed:compared with normal saline group,parecoxib group had a lower incidence of emergence agitation [relative risk(RR) =0.23,95％ Confidence interval (CI):0.15-0.34],lower RS score (Weighted mean difference =-0.85,95％ CI:-1.12--0.57),lower incidence of postoperative nausea and vomiting(RR =0.34,95％ CI:0.15-0.78),lower analgesic requirement(RR =0.09,95％ CI:0.02-0.44).Conclusion Parecoxib during preemptive analgesia can have a protective effect on emergence agitation.
Keywords：Parecoxib NaLaparoscopesEmergence agitationMeta-analysis
Publication Date：2014-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1775-1779 )