Effects of entecavir and adefovir in the treatment of chronic hepatitis B: a Meta analysis
Han Lu
Wu Yan
Yu Xiaoyan
Yuan Yongfang
Abstract：Objective To evaluate the effect of entecavir and adefovir in the treatment of patients with chronic hepatitis B.Methods Correspondent data were retrieved from database ochrane library,Pubmed,EMBASE,Chinese scientific journals database (VIP),CNKI database,Wanfang database before December 1,2013 using the key words entecavir、adefovir、randomized controlled trial 、chronic hepatitis B to collect clinical randomized controlled trials.Statistical analysis was performed by Meta-analysis using Review Manager 5.1.Results Five randomized controlled trials met the inclusion and exclusion criteria.Meta-analysis showed that patients in entecavir group had higher rates of ALT normalization(RR =1.15,95％ CI:1.03-1.29,P =0.01),lowering HBV DNA to undetectable levels (RR =2.12,95％ CI:1.69-2.65,P ＜ 0.01).The loss of HBeAg (RR =1.01,95 ％ CI:0.67-1.52,P =0.98) and HBeAg seroconversion (RR =1.70,95 ％ CI:0.91-3.17,P =0.10) had no statistical significanc.Conclusion Based on our Meta analysis results,the entecavir is superior to adefovir dipivoxil in decreasing serum HBV DNA and normalizing seruna ALT;however,as for the loss of HBeAg and HBeAg sero-conversion,the efficacies of the two drugs are similar.
Keywords：Chronic hepatitis BEntecavirAdefovirMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1768-1772 )