Value analysis of oxaliplatin combined with capecitabine treating advanced gastric cancer

Huang Huiyun; Huang Bing; Li Bin; Chang Yanxiang; Wang Jialin

doi:10.3760/cma.j.issn.1673-4777.2014.12.011

Abstract：Objective To investigate the clinical value of oxaliplatin combined with capecitabine treating advanced gastric cancer.Methods Sixty-six cases with advanced gastric cancer at first affiliated hospital of Xi'an medical university were selected and randomly divided into the observation group (33 cases) and the control group (33 cases).Patients in observation group were treated by oxaliplatin 130 mg/m2 plus capecitabine 2 500 mg/(m2 · d) chemotherapy.Patients in control group were treated by cisplatin 20 mg/m2combined with 5-fluorouracil 2 400 mg/m2,leucovorin 200 mg/m2 chemotherapy.The efficacy,quality of life and adverse drug reactions of two groups were compared.Results The effective rate of observation group was 54.5％ (18/33),which was significantly higher than that of control group [33.3％ (11/33)] (P ＜ 0.05).The quality of life score of two groups after treatment were higher than before treatment ; there were significant differences (P ＜ 0.05) [observation group:(88 ± 8) scores vs (65 ± 7) scores ; control group:(79 ± 9) scores vs (66 ± 7) scores].The quality of life score of observation group after treatment was significantly higher than that of control group (P ＜0.05).The toxic side effects of 3 ～4 such as neutrophil,hemoglobin,platelet,peripheral neurotoxicity,nausea and vomiting,diarrhea incidence were significantly lower in observation group than in the control group (P＜0.05) [30.3％(10/33) vs 3.0％ (1/33),27.3％ (9/33) vs 0.0％,21.2％ (7/33)vs 0.0％,24.2％ (8/33) vs 0.0％,24.2％ (12/33) vs 0.0％,21.2％ (7/33) vs 0.0％] ; there were no significant differences between two groups regarding hand foot syndrome and oral mucositis (P ＞ 0.05).Conclusion Oxaliplatin combined with capecitabine in the treatment of advanced gastric cancer has a high efficacy.