Effect of different doses of atorvastatin on renal function in patients with diabetes mellitus undergoing visualization
Abstract：Objective To observe the effect of different doses of atorvastatin on renal impairment caused by contrast agent in patients with diabetes mellitus (DM) who underwent visualization.Methods A total of 60 DM patients undergoing visualization were randomly divided into 20 mg atorvastatin group and 80 mg atorvastatin group ; in each group,patients took 20 mg or 80 mg atorvastatin daily 3 days before visualization.The levels of high-sensitivity CRP (hs-CRP),cystain C (CysC),urinary retinal binding protein (RBP),serum creatinine(Scr) and blood urea nitrogen (BUN) were detected before,1 and 2 days after visualization.The creatinine clearance rate (Ccr) and glomerular filtration rate(GFR) were calculated.Results CysC,GFR,urine RBP,hs-CRP in 20 mg statin group were (0.78 ± 0.35)mg/L,(104 ± 16)ml/min,(0.47 ± 0.15)mg/L and(3.7 ± 1.0)mg/L before operation ;on postoperative 1 d,they were (1.00 ± 0.46) mg/L,(85 ± 8) ml/min,(0.80 ± 0.19) mg/L,(7.8 ± 1.1)mg/L,respectively; on postoperative 2 d,they were(0.94 ±0.14) mg/L,(93 ± 18) ml/min,(0.71 ±0.23) mg/L,(9.9 ± 1.2) mg/L,respectively.CysC,GFR,urine RBP,hs-CRP in 80 mg statin group were (0.79 ± 0.41) mg/L,(102 ± 7) ml/min,(0.43 ± 0.23) mg/L,(3.6 ± 1.7) mg/L,before operation ; on postoperative 1 d,they were(0.88 ±0.41) mg/L,(94 ± 16) ml/min,(0.54 ±0.20) mg/L,(5.7 ± 1.7) mg/L,respectively; on post-operative 2 d,they were (0.82 ± 0.12) mg/L,(100 ± 16) ml/min,(0.47 ± 0.19) mg/L,(6.8 ± 1.6) mg/L,respectively.Compared with those in 20 mg statin group,serum CysC,hs-CRP,urine RBP levels in 80 mg statin group were significantly lower after operation(P ＜ 0.05).Compared with the preoperative levels in two groups,CysC,hs-CRP and uric RBP were significantly elevated on postoperative 1 d and GFR was significantly decreased (P ＜ 0.05).CIN did not occur in two groups; urea nitrogen,Scr,Ccr had no differences before and after angiography (P ＞ 0.05).Conclusion Pretreatment with high dose of atorvastatin 3 days for DM patients before visualization can effectively alleviate the renal impairment caused by contrast agent.
Keywords：Diabetes mellitusAtorvastatinHigh-sensitivity C-reactive protein
Publication Date：2014-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1756-1760 )