The relationship between clopidogrel resistance and insulin resistance in patients with acute ST-segment elevation myocardial infarction
Zeng Yaping
Nie Shaoping
Ai Hui
Abstract：Objective To investigate the relationship between clopidogrel resistance and type 2 diabetes in patients with acute ST-segment elevation myocardial infarction.Methods A total of 978 patients with acute ST-segment elevation myocardial infarction at Beijing Anzhen Hospital were enrolled in the study.The number of patients with diabetes mellitus and without diabetes mellitus was 272 cases (27.8％) and 706 cases (72.2％) respectively.Clopidogrel resistance was defined as the rate of platelet aggregation of more than 50％ induced by 5 μmol/L adenosine diphosphate.Combined endpoint events and the incidence of clopidogrel resistance were observed.Results Incidence of clopidogrel resistance was significantly higher in type 2 diabetes group than in nontype 2 diabetes group [44.1％ (120/272) vs 14.7％ (104/706),P =0.017].Combined end point event rate was significantly higher in the type 2 diabetes group than in non diabetes group[16.2％ (47/272) vs 7.4％ (52/706),P =0.012].Logistic regression analysis showed that type 2 diabetes was an independent predictor of clopidogrel resistance in acute ST-segment elevation myocardial infarction (OR:4.710,95％ CI:1.380-7.551,P =0.028).Conclusions Combined endpoint events and the incidence of clopidogrel resistance are higher in type 2 diabetes patients with acute ST-segment elevation myocardial infarction than in non diabetes patients with acute ST-segment elevation myocardial infarction.Type 2 diabetes is an independent predictor of clopidogrel resistance in acute ST-segment elevation myocardial infarction.
Keywords：Myocardial infarctionType 2 diabetesClopidogrel resistance
Publication Date：2014-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1738-1740 )