Effects of different doses of rosuvastatin on serum concentration of cardiotrophin-1 and cardiac function in acute myocardial infarction patients
Abstract：Objective To investigate the effects of different doses of rosuvastatin on serum concentration of cardiotrophin-1 (CT-1) and cardiac function in acute myocardial infarction (AMI) patients.Methods One hundred and twelve AMI patients were randomly divided into two groups.The conventional dose rosuvastatin group (60 cases) took 10 mg/d rosuvastatin in addition to routine therapy (such as aspirin clopidogrel nitrate and β-blocker) ; the strengthening dose group(52 cases) took 20mg/d rosuvastatin in addition to routine therapy.40 cases of normal physical examination were randomly selected as the control group.The levels of CT-1,left ventricular enddiastolic diameter(LVEDD),left ventricular end-systolic dimension(LVESD) and ejection fraction(EF) were all measured in three groups before and after 4 weeks treatment.Results Before treatment,the levels of CT-1,LVEDD and LVESD in the conventional dose group and the strengthening dose group [(333 ± 53) ng/L,(339 ± 51) ng/L ; (59.5 ± 6.4) mm,(58.2 ± 7.6) mm ; (40.7 ± 7.4) mm,(40.4 ± 6.2) mm] were significantly higher than those in the control group [(42.6 ± 11.2) ng/L,(38.2 ± 1.8) mm,(30.2 ± 1.2) mm] (P ＜ 0.05) ; the levels of EF[(41.1 ± 6.8)％,(41.4 ± 7.2)％] were significantly lower than those in the control group[(58.2 ± 0.9) ％] (P ＜ 0.05).After 4 weeks later,the levels of CT-1,LVEDD and LVESD were all decreased significantly [(152±28) ng/L,(108± 19)ng/L;(52.1 ±6.1) mm,(46.4 ±4.9)mm;(34.5 ±4.6)mm,(30.9 ±4.2)mm] ; the levels of EF were increased[(47.5 ± 6.1) ％,(52.8 ± 6.2) ％].Conclusion Rosuvastatin can inhibit ventricular remodeling and improve cardiac function and long term prognosis.
Keywords：Acute myocardial infarctionRosuvastatinCardiotrophin-1
Publication Date：2014-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1735-1737 )