Effect of multimodal analgesia of dezocine versus flurbiprofen in patients undergoing esophageal caner surgery
Yang Puchun
Ke Weiqi
Wang Jingwei
Yang Shaohui
Abstract：Objective To compare the effect of multimodal analgesia between dezocine and flurbiprofen axetil which were used in patients undergoing esophageal caner surgery; to investigate the feasibility of preemptive and postoperative patient-controlled intravenous analgesia (PCIA) in major surgeries.Methods Sixty patients with Americam Society of Anesthesiologists Ⅰ-Ⅱ class and undergoing esophageal caner surgery were randomly divided into dezocine group(n =30) and flurbiprofen axetil group(n =30).The single intravnous injection dezocine (0.1 mg/kg) and flurbiprofen axetil 1 mg/kg were given 5 min before anesthesia started.Anesthesia of both group patients was induced with target controlled infusion of propofol,remifentanyland intermittent cisatracurium.All patients of two groups received PCIA pump after operation according to different PCIA formula:flurbiprofen axetil group received fentanyl 0.5 mg plus dezocine 30 mg; flurbiprofen axetil group received fentanyl 0.5 mg plus flurbiprofen axetil 200 mg; tropisetron 60 mg was also added identicanlly in two groups; total PCIA volume was 100 ml saline with loading volume 2 ml,background volume 2 ml/h,bolus dose 1.5 ml and lockout time was 15 min.The visual analogue scale/score,Prince-henry and Ramsay sedation scale were recorded 1,3,6,12,24 h after surgery.Total PCIA pressing times and the adverse effects were also recorded.Results At 6,12,24 h,compared with those in flurbiprofen axetil group,the scores of Ramsay in dezocine group were significantly increased [6 h:(3.5 ±0.6)scores vs (2.2 ±0.4)scores,12 h:(2.5 ±0.5)scores vs (2.1 ±0.3)scores,24 h:(2.2 ±0.3)scores vs (2.0 ± 0.4) scores,all P ＜ 0.05].Compared with those in flurbiprofen axetil group,the total PCIA pressing times in dezocine group were significantly decreased[(10.8 ± 1.8) times vs (12.1 ± 1.3) times,P ＜ 0.05].All patients had no respiratory depression and abnormal bleeding.Compared with dezocine group,the incidence of adverse reaction in 48 h in flurbiprofen axetil group was significantly increased[dizziness:13.3％ (4/30) vs 10.0％ (3/30),nausea:20.0％(6/30) vs 13.3％(4/30),vomiting:10.0％(3/30) vs6.7％(2/30),all P＜0.05].Conclusion Dezocine and flurbiprofen axetil can be used as the multimodal analgesia in patients undergoing esophageal caner surgery.
Keywords：DezocineFlurbiprofen axetilMultimodal analgesiaPreemptive analgesiaEsophageal cancer
Publication Date：2014-11-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1638-1642 )