Influence factors of parathyroid hyperplasia during maintenance hemodialysis
Ma Junbiao
Chen Lan
Liu Fengju
Bian Weijing
Yong Qiang
Cheng Hong
Abstract：Objective To evaluate the influence factors of parathyroid hyperplasia in the maintenance hemodialysis(MHD) patients.Results A total of 71 MHD patients from March 2012 to March 2013 were included in this study.The patients were divided into parathyroid hyperplasia group(33 cases) and non-hyperplasia group (38 cases).The relation among parathyroid hyperplasia,duration of dialysis,serum calcium,phosphorus,parathyroid hormone (intact parathyroid hormone,iPTH),total alkaline phosphatase,and 25-hydroxy vitamin D levels were analyzed.Finally,receiver operating characteristic(ROC) curve was done to find out the boundary values of diagnosis parathyroid hyperplasia.Results Between the two groups,blood phosphorus,duration of dialysis and iPTH had statistical differences [(64 ± 40) months vs (44 ± 33) months,(2.2 ± 0.5) mmol/L vs (2.0 ± 0.5) mmol/L,600 (505,1 060) ng/L vs 299 (191,433) ng/L] (P ＜ 0.05 or P ＜ 0.01).Logistic regression analysis indicated that iPTH had independent correlation with parathyroid hyperplasia.ROC curve indicated that using iPTH to prompt the standard of parathyroid hyperplasia was accurate.The boundary level of iPTH prompting parathyroid hyperplasia was 513 ng/L.Conclusions Parathyroid hyperplasia is correlated with duration of dialysis and serum phosphorus.If level of iPTH is greater than 513 ng/L,it highly suggests hyperplasia of parathyroid.
Keywords：Maintenance hemodialysisParathyroid hyperplasiaInfluence factor
Publication Date：2014-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1624-1628 )