Relation between high sensitivity C-reactive protein and carotid atherosclerosis
Zhang Junwei
Wang Baohua
Yang Ying
Bai Jing
Cheng Aibin
Abstract：Objective To study the correlation between serum high sensitivity C-reactive protein (hs-CRP)and carotid atherosclerosis.Methods Totally 161 volunteers from 25 to 90 years old were collected.The serum level of hs-CRP was measured and separated into high hs-CRP group and hs-CRP normal group.The carotid atherosclerosis was detected by the color Doppler ultrasound to check intima-media thickness (IMT),followed by measurements for the state of carotid artery atherosclerosis and the rate of vessel stenosis.Results The average age in high hs-CRP group was higher than that of the hs-CRP normal group,which showed a significant difference [(60 ± 13) years vs.(48 ± 7) years,t =-7.81,P ＜ 0.01].The common carotid artery IMT,internal carotid artery IMT and carotid artery plaque for the high hs-CRP group were (0.86 ± 0.16) mm,(0.74 ± 0.11) mm,and 93.8％ (75/80) respectively,while they were(0.76 ±0.12) mm,(0.68 ± 0.06) mm and 34.6％ (28/80) in hs-CRP normal group,which demonstrates significant differences between the two groups(t =-4.39,P ＜0.01 ;t =-3.56,P ＜ 0.01 ;x2 =35.96,P ＜ 0.01).Compared to the hs-CRP normal group [18.6％ (15/81),3.7％ (3/81)],the detection rate of stenosis of the common carotid artery and internal carotid artery in high hs-CRP group was 45.0％ and 17.5％,which showed a significant difference (x2 =12.70,P ＜0.01 ;x2 =8.11,P ＜0.01).Conclusion High level of hs-CRP can enhance carotid atherosclerosis.
Keywords：High sensitivity C-reactive proteinCarotid atherosclerosisColor Doppler ultrasound
Publication Date：2014-11-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1613-1615 )